Class C3 records a modeled outcome or a certified control property. The claim reaches only as far as the model, its reachable set, and the outcome it predicts. Boundary conditions.
REVERT
Shin D, Gong JR, Jeong SD, Cho Y, Kim HP, Kim TY, Cho KH
2025 · Advanced science (Weinheim, Baden-Wurttemberg, Germany)
A cell fate change such as tumorigenesis incurs critical transition.
Abstract
From the original paper, Advanced science (Weinheim, Baden-Wurttemberg, Germany) · PubMed
A cell fate change such as tumorigenesis incurs critical transition. It remains a longstanding challenge whether the underlying mechanism can be unraveled and a molecular switch that can reverse such transition is found. Here a systems framework, REVERT, is presented with which can reconstruct the core molecular regulatory network model and a reversion switch based on single-cell transcriptome data over the transition process is identified. The usefulness of REVERT is demonstrated by applying it to single-cell transcriptome of patient-derived matched organoids of colon cancer and normal colon. REVERT is a generic framework that can be applied to investigate various cell fate transition phenomena.
Summary
Editorial summary pending review by the maintainer. The paper's own abstract appears above; the Atlas summary in the maintainer's voice will explain how REVERT relates to the inverse-design framework of the review.
Why this class
Level 3 because candidate interventions enter an explicit forward operator and the predicted post-intervention outcome is what scores each candidate. Representation family is executable intervention model. Cited in §3.4 of the review. Editorial rationale pending review by the maintainer.